My guess would be flying Rome to Split or Dubrovnik , then 3-hr bus to Medjugorje. When I went to Medjugorje a few years ago, I stopped for an evening in Assisi. If you haven't been there, you really should go. From Assisi, we went to Ancona and took a ferry across to Split another wonderful city. From there you can take and inexpensive bus to Medjugorje around in the morning. I am actually doing a trip similar in a few weeks. Have a great trip.

Rome to Medjugorje
There are 7 ways to get from Međugorje to Rome by bus, car ferry, train, car or plane
A pilgrimage tour to Italy, Croatia, Bosnia and Herzegovina that will include touring in Rome and religious activities in Medjugorge. ROME Arrival at the airport and transfer to hotel. ROME This morning set off for the famous Vatican Museum and wander through the spectacular chambers leading to the Sistine Chapel to view Michelangelo's masterpieces, including the magnificent fresco of the Last Judgment. Continue through to the awe inspiring St. Peters Basilica, the largest church in the world, for an informative exploration. Continue by coach this afternoon to the impressive St. Mary Major Basilica.
Places to see
Providing you coverage for both pre-existing conditions and those that may arise during your trip, including medical and dental emergencies, loss of luggage, trip delay, and so much more. Your meals will be served on board. After you land, collect your luggage at the baggage claims and proceed to the Arrivals Hall. This afternoon, your guide will introduce you to your fellow pilgrims and your priest who will be with you for the rest of the journey. You will make your way to Mass, followed by a welcome dinner. This evening, you may walk to St. Following breakfast, you will make your way to St.
What is the best way to get to Medjugorje from Rome?? I understand Mostar airport is the closest airport? I travelled from Italy , via Ancona by? Blue Star ferry to Split. This is an overnight trip, getting to Split early approx 7am next day. Bus departs from ferry area to Medjugorje ; trip is about 3hrs?